The TPRKB Polyclonal Antibody (PAC042678) is a valuable tool for researchers studying TPRKB, a protein involved in DNA repair processes and mitochondrial function. This antibody, produced in rabbits, is highly specific to human samples and is suitable for use in Western blot applications. By binding to the TPRKB protein, this antibody allows for the detection and analysis of TPRKB levels in various cell types, making it an ideal choice for studies in molecular biology and cancer research.TPRKB is essential for maintaining genomic stability and cellular metabolism, making it a crucial target for understanding a variety of diseases, including cancer and neurodegenerative disorders.
By investigating the role of TPRKB in DNA repair mechanisms and mitochondrial function, researchers can uncover potential therapeutic targets for treating conditions characterized by genomic instability and mitochondrial dysfunction.Overall, the TPRKB Polyclonal Antibody (PAC042678) offers researchers a reliable tool for studying TPRKB and its role in various cellular processes, providing valuable insights into the mechanisms underlying disease development and potential treatment strategies.
Western blot. All lanes: TPRKB antibody at 5µg/ml. Lane 1: A549 whole cell lysate. Lane 2: Jurkat whole cell lysate. Lane 3: MCF-7 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 20, 17, 24 kDa. Observed band size: 20 kDa.
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO42678 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human lung tissue using PACO42678 at dilution of 1:100.
Background:
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification.
TPRKB: Belongs to the CGI121/TPRKB family. 3 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 2p24.3-p24.1Cellular Component: cytoplasm; cytosol; nucleusMolecular Function: protein binding; protein kinase bindingBiological Process: tRNA processing
