The TPMT Polyclonal Antibody (CAB14067) is a valuable tool for research involving Thiopurine S-Methyltransferase (TPMT), an enzyme responsible for metabolizing thiopurine drugs used in the treatment of various diseases, including inflammatory bowel disease and leukemia. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.TPMT is a key player in determining the efficacy and toxicity of thiopurine medications, making it a crucial target for pharmacogenomic studies and personalized medicine approaches.
The TPMT Polyclonal Antibody binds specifically to TPMT protein, allowing for detection and analysis in different cell types and tissues.Research into TPMT function and regulation is essential for optimizing thiopurine drug therapy and minimizing adverse reactions in patients. By studying TPMT expression and activity, scientists can gain insights into drug metabolism, treatment outcomes, and potential drug interactions, paving the way for more personalized and effective clinical interventions.
Product Name:
TPMT Rabbit Polyclonal Antibody
SKU:
CAB14067
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-245 of human TPMT (NP_000358.1).
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.
Purification Method:
Affinity purification
Gene ID:
7172
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunofluorescence analysis of U2OS cells using TPMT antibody (CAB14067). Blue: DAPI for nuclear staining.
