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TPMT Monoclonal Antibody [PAT2E7AT] (CPAB0109)

SKU:
CPAB0109
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
PAT2E7AT
Applications:
WB
ELISA
€149
Frequently bought together:

Description

system_update_alt Datasheet

TPMT Monoclonal Antibody [PAT2E7AT] (CPAB0109)

The TPMT Polyclonal Antibody (CPAB0109) is a valuable tool for researchers studying thiopurine S-methyltransferase (TPMT), an enzyme involved in the metabolism of thiopurine drugs used in the treatment of autoimmune diseases and leukemia. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.TPMT plays a critical role in determining the efficacy and toxicity of thiopurine drugs, making it an important target for personalized medicine and precision dosing. Studies have shown that TPMT deficiency can lead to increased drug toxicity, while TPMT overactivity can result in reduced drug efficacy.

Therefore, understanding TPMT activity is essential for optimizing treatment outcomes and minimizing adverse drug reactions.The TPMT Polyclonal Antibody enables the detection and analysis of TPMT protein levels in various cell types, providing valuable insights into drug metabolism and response. By studying TPMT expression and activity, researchers can improve treatment strategies for patients receiving thiopurine therapy, ultimately enhancing therapeutic outcomes and reducing the risk of drug-related complications.

Product Name:TPMT Antibody
Product Sku:CPAB0109
Size:5μg
Host Species:Mouse
Immunogen:Anti-human TPMT mAb, is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human TPMT amino acids 1-245 purified from Ecoli.
Clone:PAT2E7AT.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:TPMT antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG1
Background:TPMT, thiopurine S-methyltransferase, is a cytosolic enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. TPMT activity exhibits autosomal codominant genetic polymorphism, and patients inheriting TPMT-deficiency are at high risk of potentially fatal hematopoietic toxicity.
Synonyms:TPMT, Thiopurine S-methyltransferase, EC 2.1.1.67, Thiopurine methyltransferase.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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