The TPM4 Polyclonal Antibody (CAB4166) is a valuable tool for researchers studying the TPM4 protein, which plays a crucial role in cell motility and maintaining cell shape. This antibody, raised in rabbits, has been validated for use in Western blot applications and is highly reactive with human samples. TPM4 is a key component of the cytoskeleton and is involved in the regulation of actin filament dynamics, leading to changes in cell shape and movement. By targeting TPM4 with this antibody, researchers can effectively study its function in various cell types and tissues, making it ideal for investigations into cell biology and cancer research.
Understanding the role of TPM4 in cellular processes is essential for unraveling its involvement in diseases such as cancer, where aberrant cell motility and shape changes contribute to disease progression. By using the TPM4 Polyclonal Antibody, researchers can gain valuable insights into the molecular mechanisms underlying these conditions and potentially identify new therapeutic targets for intervention.
Product Name:
TPM4 Rabbit Polyclonal Antibody
SKU:
CAB4166
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-248 of human TPM4 (NP_003281.1).
This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
7171
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TPM4 antibody (CAB4166) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
