The TPM3 Polyclonal Antibody (CAB13557) is a valuable tool for researchers studying TPM3, a protein involved in cell motility and cytoskeletal organization. This antibody, generated in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to TPM3, this antibody allows for accurate detection and analysis of the protein in a variety of cell types.TPM3 is a key player in regulating cell movement, making it a crucial factor in processes such as cell migration and muscle contraction.
Dysregulation of TPM3 has been implicated in various diseases, including cancer and myopathies, making it an important target for research in these areas. By understanding the function and regulation of TPM3, researchers can gain insights into the mechanisms underlying these diseases and potentially develop targeted therapies.
Product Name:
TPM3 Rabbit Polyclonal Antibody
SKU:
CAB13557
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-284 of human TPM3 (NP_689476.2).
This gene encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in autosomal dominant nemaline myopathy and other muscle disorders. This locus is involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which result in the formation of fusion proteins that act as oncogenes. There are numerous pseudogenes for this gene on different chromosomes. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
7170
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TPM3 antibody (CAB13557) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
