The TPM3 Polyclonal Antibody (CAB1206) is an essential tool for researchers studying TPM3, a key protein involved in the regulation of actin cytoskeleton dynamics. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to TPM3, this antibody enables accurate detection and analysis of the protein in various cell types, making it well-suited for investigations in cell biology and cancer research.TPM3 is a critical player in cell motility and shape maintenance, making it a crucial target for studies on cancer metastasis, cytoskeletal organization, and cell migration.
By understanding the function and regulation of TPM3, researchers can gain insights into cellular processes implicated in disease progression and potential therapeutic interventions. The TPM3 Polyclonal Antibody is a valuable tool for exploring the roles of TPM3 in physiological and pathological conditions, offering researchers a reliable means to investigate its implications in health and disease.
Product Name:
TPM3 Rabbit Polyclonal Antibody
SKU:
CAB1206
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-285 of human TPM3 (NP_689476.2).
This gene encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in autosomal dominant nemaline myopathy and other muscle disorders. This locus is involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which result in the formation of fusion proteins that act as oncogenes. There are numerous pseudogenes for this gene on different chromosomes. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
7170
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TPM3 antibody (CAB1206) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
