The TPM1 Polyclonal Antibody (CAB1157) is a valuable tool for researchers studying the tropomyosin-1 (TPM1) protein, a key component of muscle contraction and cytoskeletal organization. This antibody, produced in rabbits, exhibits high specificity and reactivity towards human TPM1, making it ideal for use in Western blot and immunohistochemistry techniques.TPM1 plays a crucial role in regulating muscle function and is implicated in various muscle-related disorders, including cardiomyopathies and skeletal muscle myopathies. By targeting TPM1 with this polyclonal antibody, researchers can investigate its expression levels and localization within different cell types and tissues, providing important insights into muscle biology and disease mechanisms.
With its high sensitivity and specificity, the TPM1 Polyclonal Antibody (CAB1157) is a valuable tool for research in muscle physiology, disease pathology, and drug development targeting TPM1-related disorders. Its versatile applications make it a valuable asset for scientists studying the role of TPM1 in health and disease.
Product Name:
Tropomyosin 1 Rabbit Polyclonal Antibody
SKU:
CAB1157
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-245 of human Tropomyosin 1 (NP_001018008.1).
This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy and dilated cardiomyopathy 1Y.
Purification Method:
Affinity purification
Gene ID:
7168
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using Tropomyosin 1 Rabbit pAb (CAB1157) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
