Tropomyosin 1 Rabbit Polyclonal Antibody (CAB1157)
- SKU:
- CAB1157
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Fish - Zebrafish
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | Tropomyosin 1 Rabbit Polyclonal Antibody |
SKU: | CAB1157 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-245 of human Tropomyosin 1 (NP_001018008.1). |
Sequence: | MAGS SSLE AVRR KIRS LQEQ ADAA EERA GTLQ RELD HERK LRET AEAD VASL NRRI QLVE EELD RAQE RLAT ALQK LEEA EKAA DESE RGMK VIES RAQK DEEK MEIQ EIQL KEAK HIAE DADR KYEE VARK LVII ESDL ERAE ERAE LSEG KCAE LEEE LKTV TNNL KSLE AQAE KYSQ KEDR YEEE IKVL SDKL KEAE TRAE FAER SVTK LEKS IDDL EDQL YQQL EQNR RLTN ELKL ALNE D |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 IHC-P,1:50 - 1:200 |
Synonyms: | CMH3; TMSA; CMD1Y; LVNC9; C15orf13; HEL-S-265; HTM-alpha; Tropomyosin 1 |
Positive Sample: | A-549,BT-474,THP-1,DU145,SW480,MCF7,Mouse heart,Mouse skeletal muscle,Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, cytoskeleton. |
Calculated MW: | 33kDa |
Observed MW: | 36kDa |
This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy and dilated cardiomyopathy 1Y.
Purification Method: | Affinity purification |
Gene ID: | 7168 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |