The TPH2 Polyclonal Antibody (CAB7147) is a valuable tool for researchers studying TPH2, an enzyme that plays a key role in serotonin synthesis in the brain and gastrointestinal tract. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the TPH2 protein, this antibody enables precise detection and analysis in various cell types, making it ideal for investigations in neuroscience and psychiatric research.TPH2, also known as tryptophan hydroxylase 2, is essential for the production of serotonin, a neurotransmitter involved in regulating mood, behavior, and cognition. Dysfunction of TPH2 and serotonin signaling has been implicated in various psychiatric disorders such as depression, anxiety, and schizophrenia.
Therefore, studying the expression and activity of TPH2 is crucial for understanding the underlying mechanisms of these conditions and developing targeted therapies.The TPH2 Polyclonal Antibody provides researchers with a reliable tool to investigate the role of TPH2 in serotonin synthesis and neurotransmission. By utilizing this antibody, scientists can further elucidate the complex interplay between TPH2 and serotonin in both physiological and pathological conditions, leading to potential advancements in the treatment of psychiatric disorders.
Product Name:
TPH2 Rabbit Polyclonal Antibody
SKU:
CAB7147
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-170 of human TPH2 (NP_775489.2).
This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.
Purification Method:
Affinity purification
Gene ID:
121278
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using TPH2 Rabbit pAb (CAB7147) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
