The TPH2 Polyclonal Antibody (CAB14520) is a valuable tool for researchers studying TPH2, an enzyme involved in the synthesis of serotonin in the brain. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications.TPH2 is a critical enzyme in the production of serotonin, a neurotransmitter that plays a key role in mood regulation and emotional well-being. Dysregulation of TPH2 has been implicated in various psychiatric disorders, including depression, anxiety, and schizophrenia.
By targeting TPH2 with this polyclonal antibody, researchers can gain insights into the enzyme's function and its impact on mental health.The TPH2 Polyclonal Antibody is an essential tool for investigating the role of TPH2 in neuronal function, as well as its potential as a therapeutic target for psychiatric disorders. Its high specificity and sensitivity make it ideal for use in studies exploring the mechanisms underlying serotonin synthesis and its implications for mental health.
Product Name:
TPH2 Rabbit Polyclonal Antibody
SKU:
CAB14520
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-70 of human TPH2 (NP_775489.2).
This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.
Purification Method:
Affinity purification
Gene ID:
121278
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using TPH2 Rabbit pAb (CAB14520) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
