The TPH1 Polyclonal Antibody (CAB1569) is a valuable tool for researchers studying TPH1, an enzyme responsible for the synthesis of serotonin in the gut and pineal gland. This antibody, generated in rabbits, exhibits high specificity and reactivity with human samples, making it ideal for use in various research applications such as Western blotting. By binding to the TPH1 protein, this antibody enables accurate detection and analysis in different cell types, offering insights into serotonin regulation and its role in neurotransmission and gut function.TPH1, also known as tryptophan hydroxylase 1, is a key enzyme in the synthesis of serotonin, a neurotransmitter with diverse functions in the central nervous system and peripheral tissues.
Dysregulation of TPH1 activity has been implicated in various neurological disorders, gastrointestinal diseases, and mood disorders. Research into TPH1 can provide valuable insights into the pathophysiology of these conditions and guide the development of novel therapeutics targeting serotonin signaling pathways. Therefore, this TPH1 Polyclonal Antibody is a valuable asset for scientists investigating the role of serotonin in health and disease.
Product Name:
TPH1 Rabbit Polyclonal Antibody
SKU:
CAB1569
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 345-444 of human TPH1 (NP_004170.1).
This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.
Purification Method:
Affinity purification
Gene ID:
7166
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and 293F cells transfected with TPH1 using TPH1 Rabbit pAb (CAB1569) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90 s.
