The TPCN1 Polyclonal Antibody (CAB15847) is a valuable tool for researchers studying the TPCN1 protein, which is a member of the two-pore channel family involved in regulating calcium release from acidic organelles. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications, enabling the detection and analysis of TPCN1 in various cell types.TPCN1 plays a crucial role in intracellular calcium signaling and ion homeostasis, making it a key player in processes such as neurotransmitter release, autophagy, and lysosomal function. Dysfunction in TPCN1 has been linked to various diseases, including neurodegenerative disorders and metabolic conditions, making it a promising target for therapeutic interventions.
With its high specificity and sensitivity, the TPCN1 Polyclonal Antibody is an essential tool for researchers seeking to unravel the complexities of calcium signaling and cellular homeostasis. Its application in a wide range of research areas, including neuroscience, metabolism, and cell biology, makes it a versatile reagent for advancing our understanding of TPCN1's function and its potential implications in human health and disease.
Product Name:
TPCN1 Rabbit Polyclonal Antibody
SKU:
CAB15847
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 692-816 of human TPCN1 (NP_060371.2).
Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000 [PubMed 10753632]).
Purification Method:
Affinity purification
Gene ID:
53373
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from rat lung, using TPCN1 Rabbit pAb (CAB15847) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
