The TP63 Polyclonal Antibody (CAB12968) is a vital tool for researchers investigating the TP63 protein, a transcription factor that plays a pivotal role in regulating cell growth and differentiation. This antibody, generated in rabbits, boasts high specificity for human samples and has been rigorously validated for use in Western blotting applications. Its ability to specifically bind to TP63 enables precise detection and analysis in a variety of cell types, making it invaluable for studies in fields such as cancer biology and developmental biology.
TP63, a member of the p53 family of transcription factors, serves as a critical regulator of cellular processes such as cell cycle progression, apoptosis, and stem cell maintenance. Dysregulation of TP63 has been implicated in various human diseases, including cancer, developmental disorders, and age-related conditions. By delving into the functions and mechanisms of TP63, researchers can gain crucial insights into disease pathogenesis and potentially identify new therapeutic targets for intervention.
Product Name:
p63 Rabbit Polyclonal Antibody
SKU:
CAB12968
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human p63 (NP_003713.3).
This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8.
Purification Method:
Affinity purification
Gene ID:
8626
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using p63 Rabbit pAb (CAB12968) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
