The TP63 Polyclonal Antibody (PAC060909) is a valuable tool for researchers studying the TP63 protein, a key player in cell growth and differentiation processes. This antibody, derived from rabbit serum, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the TP63 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential component for studies in cancer biology and developmental biology.TP63, also known as tumor protein p63, is a crucial regulator of cell proliferation and differentiation, particularly in epithelial tissues.
Dysregulation of TP63 has been implicated in various cancers, making it a promising target for cancer research and therapy development. By understanding the function and expression of TP63, researchers can gain insights into cancer progression and potentially identify new therapeutic strategies for combating this disease.Overall, the TP63 Polyclonal Antibody (PAC060909) offers researchers a reliable tool for investigating the role of TP63 in cellular processes, paving the way for advancements in cancer research and therapeutic interventions.
Antibody Name:
tp63 Antibody (PACO60909)
Antibody SKU:
PACO60909
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:
Zebrafish
Immunogen:
Recombinant Zebrafish Tumor protein p63 protein (41-153AA)
Western Blot. Positive WB detected in Recombinant protein. All lanes: tp63 antibody at 7.3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 43 kDa. Observed band size: 43, 52 kDa.
Background:
chromatin, cytosol, dendrite, nucleus, transcription factor complex, chromatin binding, damaged DNA binding, DNA binding, double-stranded DNA binding, p53 binding
Synonyms:
Tumor protein 63 (p63) (Chronic ulcerative stomatitis protein) (CUSP) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (p40) (p51), TP63, KET P63 P73H P73L TP73L
UniProt Protein Function:
Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.
