The TP53INP2 Antibody (PAC023263) is a valuable tool for researchers studying the TP53INP2 protein, which plays a crucial role in cellular stress responses and regulation of apoptosis. This polyclonal antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.TP53INP2, also known as tumor protein p53-inducible nuclear protein 2, is involved in mediating the cellular response to DNA damage and oxidative stress, making it a key player in maintaining genomic stability. Dysregulation of TP53INP2 has been implicated in various diseases, including cancer and neurodegenerative disorders, highlighting its importance in cellular homeostasis.
By utilizing the TP53INP2 Antibody, researchers can detect and analyze the expression of TP53INP2 in different cell types and tissues, providing insights into its role in disease development and progression. This antibody is a valuable tool for studying molecular mechanisms involved in cellular stress responses and may lead to the development of new therapeutic strategies targeting TP53INP2 in various pathological conditions.
Synthesized peptide derived from internal of human TP53INP2.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using TP53INP2 antibody.
Immunofluorescence analysis of MCF-7 cells, using TP53INP2 antibody.
Background:
Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA.
Synonyms:
p53-inducible protein U; PIG-U; PINH; T53I2; tumor protein p53 inducible nuclear protein 2
UniProt Protein Function:
TP53INP2: Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA.Cellular Component: cytoplasm; autophagic vacuole; cytoplasmic vesicle; cytosol; nucleusBiological Process: osteoblast differentiation; transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; autophagy; positive regulation of autophagy; autophagic vacuole formation
