The TP53INP2 Polyclonal Antibody (PACO04856) is a valuable tool for researchers studying TP53INP2, a protein involved in regulating cell growth and apoptosis. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for Western blot applications. By targeting the TP53INP2 protein, researchers can investigate its role in various cellular processes and diseases, particularly cancer.TP53INP2, also known as tumor protein p53-inducible nuclear protein 2, is a key player in cell cycle regulation and DNA damage response. Dysregulation of TP53INP2 has been implicated in tumorigenesis and cancer progression, making it a promising target for therapeutic interventions.
Research on TP53INP2 can provide insights into potential treatment strategies for cancer and other related conditions.By utilizing the TP53INP2 Polyclonal Antibody, researchers can delve deeper into the functions and pathways involving TP53INP2, advancing our understanding of its role in disease development and progression. This antibody is a valuable resource for studies focusing on cancer biology, molecular mechanisms, and potential therapeutic targets.
Antibody Name:
TP53INP2 Antibody
Antibody SKU:
PACO04856
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC, IF
Recommended Dilutions:
IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the N-terminal region of human TP53INP2.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
TP53INP2; C20orf110; DOR; PINH; Tumor protein p53-inducible nuclear protein 2; Diabetes and obesity-regulated gene; p53-inducible protein U; PIG-U
UniProt Protein Function:
TP53INP2: Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA.Chromosomal Location of Human Ortholog: 20q11.22Cellular Component: autophagic vacuole; cytoplasmic vesicle; cytosol; nucleus; PML bodyMolecular Function: protein binding; ubiquitin bindingBiological Process: autophagic vacuole formation; osteoblast differentiation; positive regulation of autophagy; positive regulation of transcription, DNA-dependent; tissue homeostasis; transcription, DNA-dependent; ubiquitin-dependent protein catabolic process
