The TP53BP2 Polyclonal Antibody is a valuable tool for researchers studying TP53BP2, a protein involved in the DNA damage response pathway. This antibody is produced in rabbits and exhibits high reactivity with human samples, making it suitable for Western blot applications. By binding specifically to the TP53BP2 protein, this antibody enables the efficient detection and analysis of TP53BP2 levels in various cell types.TP53BP2, also known as tumor protein p53 binding protein 2, plays a crucial role in mediating the cellular response to DNA damage, thereby safeguarding genomic integrity and preventing tumorigenesis. Dysregulation of TP53BP2 has been linked to various human diseases, including cancer, making it a promising target for therapeutic interventions.
Research on TP53BP2 is essential for understanding its function in DNA repair mechanisms and its potential implications in disease development.Overall, the TP53BP2 Polyclonal Antibody is a reliable tool for investigating the roles and functions of TP53BP2 in cellular processes and disease pathogenesis. Its specificity and sensitivity make it a valuable asset for researchers in the fields of molecular biology, cancer biology, and genomics. By utilizing this antibody, researchers can gain valuable insights into TP53BP2-mediated pathways and potentially identify novel therapeutic strategies for combating diseases associated with TP53BP2 dysregulation.
Product Name:
TP53BP2 Polyclonal Antibody
SKU:
CAB21633
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 200-330 of TP53BP2 (NP_001026855.2).
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
7159
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TP53BP2 Rabbit pAb (CAB21633) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
