The TP53BP2 Polyclonal Antibody (CAB5704) is specially designed for research involving TP53BP2, a protein associated with DNA damage response and cell cycle regulation. This antibody, raised in rabbits, is highly reactive with human samples and validated for use in various applications such as Western blotting. It specifically binds to the TP53BP2 protein, allowing for precise detection and analysis in a wide range of cell types.TP53BP2, also known as tumor protein p53 binding protein 2, plays a crucial role in maintaining genomic stability and coordinating cellular responses to DNA damage. Dysregulation of TP53BP2 has been implicated in various diseases, including cancer and neurodegenerative disorders.
Understanding the functions and regulation of TP53BP2 is essential for elucidating its role in disease development and progression.By using the TP53BP2 Polyclonal Antibody (CAB5704), researchers can further investigate the mechanisms of TP53BP2 activity in different biological contexts, leading to insights that may pave the way for new therapeutic interventions targeting TP53BP2-related pathways. This antibody is a valuable tool for studies in molecular biology, cancer research, and genomics, providing researchers with a precise and reliable method for detecting and studying TP53BP2 protein expression.
Product Name:
TP53BP2 Rabbit Polyclonal Antibody
SKU:
CAB5704
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 360-600 of human TP53BP2 (NP_001026855.2).
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
7159
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded Rat brain using TP53BP2 Rabbit pAb (CAB5704) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
