The TP53BP2 Polyclonal Antibody (CAB15105) is a valuable tool for researchers studying the TP53BP2 protein, which is involved in DNA damage response and cell cycle regulation. This antibody, raised in rabbits, exhibits high reactivity with human samples and is suitable for Western blot applications. By binding specifically to the TP53BP2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an ideal choice for investigations in molecular biology and cancer research.TP53BP2, also known as tumor protein p53 binding protein 2, plays a crucial role in maintaining genomic stability and preventing the propagation of damaged DNA.
Dysregulation of TP53BP2 has been implicated in various cancers and genetic disorders, highlighting its importance in cellular processes. Research focused on understanding the functions of TP53BP2 can provide insights into mechanisms of disease development and potential therapeutic targets for cancer treatment.Overall, the TP53BP2 Polyclonal Antibody is a reliable tool for researchers seeking to explore the role of TP53BP2 in DNA damage response pathways and its implications for human health and disease. Its specificity and sensitivity make it a valuable asset for studies aimed at uncovering the molecular mechanisms underlying TP53BP2 function.
Product Name:
TP53BP2 Rabbit Polyclonal Antibody
SKU:
CAB15105
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant Protein corresponding to a sequence within amino acids 200-330 of TP53BP2 (NP_001026855.2).
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
7159
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Jurkat cells using TP53BP2 Rabbit pAb(CAB15105) at 1:1000 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection:ECL Basic Kit (AbGn00020).Exposuretime:30s.
