[KO Validated] p53 Rabbit Polyclonal Antibody (CAB11232)
- SKU:
- CAB11232
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | [KO Validated] p53 Rabbit Polyclonal Antibody |
SKU: | CAB11232 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 95-390 of mouse p53 (NP_035770.2). |
Sequence: | PSQK TYQG NYGF HLGF LQSG TAKS VMCT YSPP LNKL FCQL AKTC PVQL WVSA TPPA GSRV RAMA IYKK SQHM TEVV RRCP HHER CSDG DGLA PPQH LIRV EGNL YPEY LEDR QTFR HSVV VPYE PPEA GSEY TTIH YKYM CNSS CMGG MNRR PILT IITL EDSS GNLL GRDS FEVR VCAC PGRD RRTE EENF RKKE VLCP ELPP GSAK RALP TCTS ASPP QKKK PLDG EYFT LKIR GRKR FEMF RELN EALE LKDA HATE ESGD SRAH SSYL KTKK GQST SRHK KTMV KKVG PDSD |
Tested Applications: | IHC-P IF/ICC ELISA |
Recommended Dilution: | IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | bbl; bfy; bhy; p44; p53; Tp53 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Endoplasmic reticulum, Mitochondrion matrix, Nucleus, PML body. |
Calculated MW: | 43kDa |
This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mice deficient for this gene are developmentally normal but are susceptible to spontaneous tumors. Evidence to date shows that this gene contains one promoter, in contrast to alternative promoters of the human gene, and transcribes a few of splice variants which encode different isoforms, although the biological validity or the full-length nature of some variants has not been determined.
Purification Method: | Affinity purification |
Gene ID: | 22059 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |