TOX3 Antibody (PACO46290)
- SKU:
- PACO46290
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
TOX3 Antibody (PACO46290)
The TOX3 Polyclonal Antibody (PAC046290) is an essential tool for researchers studying the TOX3 protein, a key regulator of gene expression in breast cancer development. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting TOX3 in human samples, making it ideal for use in Western blot applications. By binding to TOX3, the antibody enables accurate detection and analysis of the protein in various cell types, facilitating investigations in cancer biology and drug discovery.
TOX3 is a transcription factor that plays a crucial role in controlling gene expression and cell proliferation, particularly in breast cancer cells. Its dysregulation has been linked to tumor growth and metastasis, highlighting its potential as a therapeutic target for breast cancer treatment. Research on TOX3 may lead to the development of novel therapies that specifically target breast cancer cells while sparing normal tissues, improving outcomes for patients with this disease.
| Antibody Name: | TOX3 Antibody (PACO46290) |
| Antibody SKU: | PACO46290 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human TOX high mobility group box family member 3 protein (8-305AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: TOX3 antibody at 9 µg/ml. Lane 1: Mouse heart tissue. Lane 2: Mouse spleen tissue. Lane 3: Mouse brain tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 63 kDa. Observed band size: 63, 24 kDa.. |
 | Immunofluorescent analysis of HepG2 cells using PACO46290 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human brain tissue using PACO46290 at dilution of 1:100. |
| Background: | Transcriptional coactivator of the p300/CBP-mediated trancription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region. |
| Synonyms: | TOX high mobility group box family member 3 (CAG trinucleotide repeat-containing gene F9 protein) (Trinucleotide repeat-containing gene 9 protein), TOX3, CAGF9 TNRC9 |
| UniProt Protein Function: | TOX3: Transcriptional coactivator of the p300/CBP-mediated trancription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 16q12.1Molecular Function: chromatin binding; estrogen response element binding; phosphoprotein binding; protein binding; protein homodimerization activityBiological Process: negative regulation of neuron apoptosis; positive regulation of transcription, DNA-dependent |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009] |
| UniProt Code: | O15405 |
| NCBI GenInfo Identifier: | 146325793 |
| NCBI Gene ID: | 27324 |
| NCBI Accession: | O15405.2 |
| UniProt Secondary Accession: | O15405,B4DRD0, B5MCW4 |
| UniProt Related Accession: | O15405 |
| Molecular Weight: | 63,100 Da |
| NCBI Full Name: | TOX high mobility group box family member 3 |
| NCBI Synonym Full Names: | TOX high mobility group box family member 3 |
| NCBI Official Symbol: | TOX3Â Â |
| NCBI Official Synonym Symbols: | CAGF9; TNRC9Â Â |
| NCBI Protein Information: | TOX high mobility group box family member 3 |
| UniProt Protein Name: | TOX high mobility group box family member 3 |
| UniProt Synonym Protein Names: | CAG trinucleotide repeat-containing gene F9 protein; Trinucleotide repeat-containing gene 9 protein |
| Protein Family: | TOX high mobility group box family |
| UniProt Gene Name: | TOX3Â Â |
| UniProt Entry Name: | TOX3_HUMAN |
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