The Tox Polyclonal Antibody (CAB7050) is a crucial tool for researchers studying Tox, a transcription factor that plays a key role in T cell exhaustion. This antibody is produced in rabbits and has high reactivity with human samples, making it a reliable tool for Western blot applications. By binding to the Tox protein, this antibody allows for easy detection and analysis in various cell types, making it ideal for studies in immunology and cancer research.Tox, also known as Thymocyte selection-associated high mobility group box protein, is a critical regulator of T cell dysfunction and exhaustion in the context of chronic infections, cancer, and autoimmune diseases.
Understanding the role of Tox in immune response modulation is essential for the development of novel therapies that target T cell exhaustion in these diseases. The Tox Polyclonal Antibody provides researchers with a powerful tool to investigate the role of Tox in immune regulation and disease pathogenesis.
Product Name:
TOX Rabbit Polyclonal Antibody
SKU:
CAB7050
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 30-165 of human TOX (NP_055544.1).
The protein encoded by this gene contains a HMG box DNA binding domain. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. This protein may function to regulate T-cell development.
Purification Method:
Affinity purification
Gene ID:
9760
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse brain, using TOX Rabbit pAb (CAB7050) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
