Topors Rabbit Polyclonal Antibody (CAB18526)
- SKU:
- CAB18526
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | Topors Rabbit Polyclonal Antibody |
SKU: | CAB18526 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of mouse Topors (NP_598858.2). |
Sequence: | PDSK CPIC LDRF DNVS YLDR CLHK FCFR CVQE WSKN KAEC PLCK QPFD SIFH SVRA EDDF KEYV LRPS YNGS FTNP EVRR FRYR TTMT RERS ASLY SPSS T |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | LUN; TP53BPL; p53BP3/LUN; Topors |
Positive Sample: | Mouse liver,Mouse lung,Mouse kideny,Rat kidney |
Cellular Localization: | centriole, ciliary basal body, gamma-tubulin complex, nuclear speck, nucleoplasm, nucleus, PML body, spindle pole |
Calculated MW: | 117kDa |
Observed MW: | 119kDa |
Predicted to enable several functions, including DNA topoisomerase binding activity; antigen binding activity; and ubiquitin-like protein transferase activity. Acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of transcription, DNA-templated; and regulation of cell population proliferation. Located in ciliary basal body; nucleus; and photoreceptor connecting cilium. Is expressed in skin. Human ortholog(s) of this gene implicated in retinitis pigmentosa 31. Orthologous to human TOPORS (TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase).
Purification Method: | Affinity purification |
Gene ID: | 106021 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |