The TOPORS Polyclonal Antibody (CAB18526) is a versatile tool for researchers studying the TOPORS protein, a key regulator of DNA damage response and tumor suppression. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the TOPORS protein, this antibody enables precise detection and analysis in various cell types, making it an ideal choice for investigations in cancer biology and DNA repair mechanisms.
TOPORS, or Topoisomerase I-binding arginine/serine-rich protein, is a crucial player in maintaining genomic stability and preventing the accumulation of DNA damage that can lead to tumorigenesis. Its role in mediating DNA repair processes and suppressing tumor growth highlights its potential as a therapeutic target in cancer treatment. By elucidating the functions of TOPORS, researchers can gain insights into the mechanisms underlying cancer development and identify novel strategies for anti-cancer therapy.
Product Name:
Topors Rabbit Polyclonal Antibody
SKU:
CAB18526
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of mouse Topors (NP_598858.2).
Predicted to enable several functions, including DNA topoisomerase binding activity; antigen binding activity; and ubiquitin-like protein transferase activity. Acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of transcription, DNA-templated; and regulation of cell population proliferation. Located in ciliary basal body; nucleus; and photoreceptor connecting cilium. Is expressed in skin. Human ortholog(s) of this gene implicated in retinitis pigmentosa 31. Orthologous to human TOPORS (TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase).
Purification Method:
Affinity purification
Gene ID:
106021
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Topors Rabbit pAb (CAB18526) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
