TOP3B Rabbit Polyclonal Antibody (CAB8469)
- SKU:
- CAB8469
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | TOP3B Rabbit Polyclonal Antibody |
SKU: | CAB8469 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human TOP3B (NP_003926.1). |
Sequence: | MKTV LMVA EKPS LAQS IAKI LSRG SLSS HKGL NGAC SVHE YTGT FAGQ PVRF KMTS VCGH VMTL DFLG KYNK WDKV DPAE LFSQ APTE KKEA NPKL NMVK FLQV EGRG CDYI VLWL DCDK EGEN ICFE VLDA VLPV MNKA HGGE KTVF RARF SSIT DTDI CNAM ACLG EPDH NEAL SVDA RQEL DLRI GCAF TRFQ TKYF QGKY GDLD SSLI SFGP CQTP TLGF CVER HDKI QSFK PETY WVLQ AKVN TDKD RSLL LDWD RVRV FDRE IA |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | TOP3B1; TOP3B |
Positive Sample: | 293T,A-431,HT-1080,BT-474,HL-60,Rat thymus |
Conjugate: | Unconjugated |
Cellular Localization: | nucleus |
Calculated MW: | 97kDa |
Observed MW: | 120kDa |
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
Purification Method: | Affinity purification |
Gene ID: | 8940 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |