DNA topoisomerase I (TOP1) Rabbit Polyclonal Antibody (CAB12524)
- SKU:
- CAB12524
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
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Description
Product Name: | DNA topoisomerase I (TOP1) Rabbit Polyclonal Antibody |
SKU: | CAB12524 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human DNA topoisomerase I (DNA topoisomerase I (TOP1)) (NP_003277.1). |
Sequence: | MSGD HLHN DSQI EADF RLND SHKH KDKH KDRE HRHK EHKK EKDR EKSK HSNS EHKD SEKK HKEK EKTK HKDG SSEK HKDK HKDR DKEK RKEE KVRA SGDA |
Tested Applications: | WB IHC-P IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | TOPI; DNA topoisomerase I (TOP1) |
Positive Sample: | MCF7,SKOV3,SW480,Jurkat,HeLa,Mouse spleen,Mouse ovary |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus, nucleolus, nucleoplasm. |
Calculated MW: | 91kDa |
Observed MW: | 120kDa |
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22.
Purification Method: | Affinity purification |
Gene ID: | 7150 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |