The TONSL Polyclonal Antibody (CAB13035) is specifically designed for research involving the TONSL protein, a key player in DNA repair and genome stability. This antibody is produced in rabbits and exhibits high reactivity with human samples, making it a reliable tool for Western blot applications.The TONSL antibody targets the TONSL protein, allowing for accurate detection and analysis in various cell types. This makes it an ideal choice for studies focusing on DNA repair mechanisms, genotoxic stress responses, and overall genomic stability. Researchers in the fields of molecular biology, genetics, and oncology will find this antibody invaluable for investigating the role of TONSL in maintaining DNA integrity and preventing mutations.
Given the critical importance of TONSL in safeguarding the genome from damage, understanding its function and regulation is essential for developing targeted therapies for diseases related to DNA repair deficiencies, such as cancer and genetic disorders. By utilizing the TONSL Polyclonal Antibody, researchers can further advance our knowledge of genome maintenance and potentially uncover new strategies for treating these devastating conditions.
Product Name:
TONSL Rabbit Polyclonal Antibody
SKU:
CAB13035
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 160-390 of human TONSL (NP_038460.4).
The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus.
Purification Method:
Affinity purification
Gene ID:
4796
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TONSL Rabbit pAb (CAB13035) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
