The Tollip Polyclonal Antibody is a valuable tool for researchers studying Tollip, a protein involved in immune regulation and inflammatory responses. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By targeting the Tollip protein, this antibody allows for the detection and analysis of Tollip in various cell types, making it ideal for studies in immunology, inflammation, and infectious disease research.Tollip is a key player in the regulation of toll-like receptor signaling pathways, which are essential for initiating immune responses to invading pathogens.
Dysregulation of Tollip has been implicated in various inflammatory disorders, making it a promising target for therapeutic interventions. By investigating the role of Tollip in immune regulation, researchers can gain valuable insights into the mechanisms underlying immune dysfunction and potentially identify new targets for drug development.
Product Name:
[KD Validated] TOLLIP Polyclonal Antibody
SKU:
CAB21551
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-274 of human TOLLIP (NP_061882.2).
This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
54472
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TOLLIP antibody (CAB21551) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3S.
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