UniProt Protein Function: | Function: Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. Ref.8 Ref.11 Ref.12 Ref.13Subunit structure: Interacts with one or more of the argonaute family proteins AGO1, AGO2, AGO3 and AGO4. Interacts with PABPC1 and EIF4G1. Interacts with CNOT1; the interaction is direct and mediates the association with the CCR4-NOT complex. Interacts with PAN3; the interaction mediates the association with the PAN complex. Ref.7 Ref.8 Ref.9 Ref.11 Ref.12 Ref.13Domain: The silencing domain, also known as C-terminal effector domain (CED), can act in autonomous repression, including both translational inhibition and mRNA degradation.Sequence similarities: Belongs to the GW182 family.Contains 1 RRM (RNA recognition motif) domain.Contains 1 UBA domain.Sequence caution: The sequence BAB13408.2 differs from that shown. Reason: Erroneous initiation. The sequence BAB71179.1 differs from that shown. Reason: Erroneous initiation. |
UniProt Protein Details: | |
NCBI Summary: | |
UniProt Code: | Q9HCJ0 |
NCBI GenInfo Identifier: | 33413425 |
NCBI Gene ID: | 57690 |
NCBI Accession: | NP_061869 |
UniProt Secondary Accession: | Q9HCJ0 |
UniProt Related Accession: | Q9HCJ0 |
Molecular Weight: | |
NCBI Full Name: | trinucleotide repeat-containing gene 6C protein isoform 2 |
NCBI Synonym Full Names: | trinucleotide repeat containing adaptor 6C |
NCBI Official Symbol: | TNRC6CÂ Â |
NCBI Official Synonym Symbols: | |
NCBI Protein Information: | trinucleotide repeat-containing gene 6C protein |
UniProt Protein Name: | Trinucleotide repeat-containing gene 6C protein |
UniProt Synonym Protein Names: | |
Protein Family: | Trinucleotide repeat-containing gene 6C protein |
UniProt Gene Name: | TNRC6CÂ Â |
UniProt Entry Name: | TNR6C_HUMAN |