The TNP1 Polyclonal Antibody (PAC05066) is an essential tool for researchers studying TNP1, a key protein involved in spermatogenesis and male fertility. This antibody, produced in rabbits, exhibits high specificity towards human samples and is validated for use in various applications, including Western blotting.TNP1, also known as transition protein 1, is essential for the proper packaging of DNA during spermatogenesis, ensuring the correct transmission of genetic material to progeny.
Dysregulation of TNP1 has been implicated in male infertility and reproductive disorders, making it a target of interest for researchers in the field.By using the TNP1 Polyclonal Antibody, researchers can accurately detect and analyze TNP1 expression in different cell types, providing valuable insights into its function and role in male reproductive health. This antibody is a valuable tool for studies focusing on fertility, reproductive biology, and genetics-related research.
Antibody Name:
TNP1 Antibody (PACO50066)
Antibody SKU:
PACO50066
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Spermatid nuclear transition protein 1 protein (12-50AA)
Immunofluorescent analysis of Hela cells using PACO50066 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins.
Synonyms:
Spermatid nuclear transition protein 1 (STP-1) (TP-1), TNP1
UniProt Protein Function:
Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
UniProt Protein Details:
NCBI Summary:
Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880; PRM2, MIM 182890) (Luerssen et al., 1990 [PubMed 2249851]).[supplied by OMIM, Mar 2008]
