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Tnnt2 Antibody (PACO30718)

SKU:
PACO30718
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
Frequently bought together:

Description

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Tnnt2 Antibody (PACO30718)

The TNNT2 Polyclonal Antibody (PAC030718) is a valuable tool for researchers studying cardiac muscle development and function. This antibody, raised in rabbits, is highly specific to the TNNT2 protein and is validated for use in various applications, including Western blot and immunohistochemistry.TNNT2, also known as cardiac troponin T, is a key regulatory protein involved in muscle contraction in the heart. Mutations in the TNNT2 gene have been linked to various cardiac disorders, making it an important target for research in cardiology and cardiovascular medicine.

By using the TNNT2 Polyclonal Antibody, researchers can study the expression and localization of TNNT2 in cardiac tissue, gaining insights into its role in normal physiology and disease pathology.Overall, the TNNT2 Polyclonal Antibody is a reliable tool that enables precise detection and analysis of TNNT2 in various experimental settings, providing valuable information for advancing our understanding of cardiac muscle biology and developing new therapeutic approaches for heart-related conditions.

Antibody Name:Tnnt2 Antibody (PACO30718)
Antibody SKU:PACO30718
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Mouse
Immunogen:Recombinant Mouse Troponin T, cardiac muscle protein (2-301AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Synonyms:Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT), Tnnt2
UniProt Protein Function:TNNT2: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. Belongs to the troponin T family. 11 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Motor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: sarcomere; troponin complex; cytosol; striated muscle thin filament

Molecular Function:troponin C binding; structural constituent of cytoskeleton; troponin I binding; ATPase activity; tropomyosin binding; actin binding

Biological Process: positive regulation of ATPase activity; regulation of muscle contraction; atrial cardiac muscle morphogenesis; metabolic process; ventricular cardiac muscle morphogenesis; sarcomere organization; response to calcium ion; negative regulation of ATPase activity; regulation of heart contraction; muscle filament sliding

Disease: Cardiomyopathy, Familial Restrictive, 3; Cardiomyopathy, Dilated, 1d; Cardiomyopathy, Familial Hypertrophic, 2

NCBI Summary:The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
UniProt Code:P50752
NCBI GenInfo Identifier:15290516
NCBI Gene ID:7139
NCBI Accession:AAK92231.1
UniProt Secondary Accession:P50752,P50752,
UniProt Related Accession:P45379
Molecular Weight:
NCBI Full Name:cardiac troponin T
NCBI Synonym Full Names:troponin T2, cardiac type
NCBI Official Symbol:TNNT2  
NCBI Official Synonym Symbols:CMH2; RCM3; TnTC; cTnT; CMD1D; CMPD2; LVNC6  
NCBI Protein Information:troponin T, cardiac muscle
UniProt Protein Name:Troponin T, cardiac muscle
UniProt Synonym Protein Names:Cardiac muscle troponin T
UniProt Gene Name:TNNT2  
UniProt Entry Name:TNNT2_HUMAN

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