TNNT1 Rabbit Polyclonal Antibody (CAB10354)
- SKU:
- CAB10354
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | TNNT1 Rabbit Polyclonal Antibody |
SKU: | CAB10354 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-262 of human TNNT1 (NP_001119604.1). |
Sequence: | MSDT EEQE YEEE QPEE EAAE EEEE APEE PEPV AEPE EERP KPSR PVVP PLIP PKIP EGER VDFD DIHR KRME KDLL ELQT LIDV HFEQ RKKE EEEL VALK ERIE RRRS ERAE QQRF RTEK ERER QAKL AEEK MRKE EEEA KKRA EDDA KKKK VLSN MGAH FGGY LVKA EQKR GKRQ TGRE MKVR ILSE RKKP LDID YMGE EQLR EKAQ ELSD WIHQ LESE KFDL MAKL KQQK YEIN VLYN RISH AQKF RKGA GKGR VGGR WK |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | ANM; TNT; NEM5; STNT; TNTS; TNNT1 |
Positive Sample: | HT-1080,A-549,SW480 |
Conjugate: | Unconjugated |
Cellular Localization: | cytosol |
Calculated MW: | 33kDa |
Observed MW: | 33kDa |
This gene encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 7138 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |