Tnni3 Antibody (PACO52194)
- SKU:
- PACO52194
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Tnni3 Antibody (PACO52194)
The TNNI3 Polyclonal Antibody (PAC052194) is a valuable tool for researchers studying the troponin I, cardiac muscle 3 (TNNI3) protein, which plays a critical role in regulating cardiac muscle contraction. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.The TNNI3 protein is essential for proper muscle function, and mutations in the TNNI3 gene have been associated with various heart conditions, including hypertrophic cardiomyopathy and dilated cardiomyopathy.
By targeting the TNNI3 protein, researchers can investigate the mechanisms underlying these cardiac disorders and explore potential therapeutic approaches.This antibody enables the specific detection and analysis of TNNI3 in different cell types, making it an ideal choice for studies in cardiology and cardiovascular research. By understanding the role of TNNI3 in cardiac muscle physiology, researchers can work towards developing improved diagnostic tools and treatment strategies for heart diseases.
| Antibody Name: | Tnni3 Antibody (PACO52194) |
| Antibody SKU: | PACO52194 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Mouse, Rat |
| Immunogen: | Recombinant Mouse Troponin I, cardiac muscle protein (2-211AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Rat heart tissue, Rat liver tissue. All lanes: Tnni3 antibody at 2.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 25 kDa. Observed band size: 25 kDa. |
| Background: | Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| Synonyms: | Troponin I, cardiac muscle (Cardiac troponin I), Tnni3 |
| UniProt Protein Function: | TNNI3: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Binds to actin and tropomyosin. Interacts with TRIM63. Interacts with STK4/MST1. Belongs to the troponin I family. |
| UniProt Protein Details: | Protein type:Actin-binding; Motor; Motility/polarity/chemotaxis Cellular Component: contractile fiber; cytoplasm; myofibril; sarcomere; troponin complex Molecular Function:actin binding; calcium channel inhibitor activity; calcium-dependent protein binding; metal ion binding; protein domain specific binding; protein kinase binding; troponin C binding; troponin T binding Biological Process: cardiac muscle contraction; cellular calcium ion homeostasis; heart contraction; heart development; negative regulation of ATPase activity; regulation of muscle contraction; regulation of smooth muscle contraction; regulation of systemic arterial blood pressure by ischemic conditions; skeletal muscle contraction; striated muscle contraction; vasculogenesis; ventricular cardiac muscle morphogenesis |
| UniProt Code: | P48787 |
| NCBI GenInfo Identifier: | 6678393 |
| NCBI Gene ID: | 21954 |
| NCBI Accession: | NP_033432.1 |
| UniProt Related Accession: | P48787 |
| Molecular Weight: | |
| NCBI Full Name: | troponin I, cardiac muscle |
| NCBI Synonym Full Names: | troponin I, cardiac 3 |
| NCBI Official Symbol: | Tnni3Â Â |
| NCBI Official Synonym Symbols: | Tn1; cTnIÂ Â |
| NCBI Protein Information: | troponin I, cardiac muscle |
| UniProt Protein Name: | Troponin I, cardiac muscle |
| UniProt Synonym Protein Names: | Cardiac troponin I |
| UniProt Gene Name: | Tnni3Â Â |
| UniProt Entry Name: | TNNI3_MOUSE |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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