The TNni2 Rabbit Monoclonal Antibody (CAB4740) is a high-quality antibody designed for the study of Troponin I, a protein involved in muscle contraction. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it ideal for research in cardiology and muscle physiology.Troponin I is a key regulatory protein in the troponin complex, which controls the contraction of striated muscle tissue. Elevated levels of Troponin I in the bloodstream are a sensitive and specific marker of myocardial injury, making it an important diagnostic tool for detecting heart attacks and other cardiac conditions.The TNni2 Rabbit Monoclonal Antibody binds specifically to Troponin I, allowing for accurate detection and quantification in various samples and tissues.
Its sensitivity and specificity make it an invaluable tool for studying cardiac muscle damage, assessing heart function, and developing new diagnostic and therapeutic strategies for cardiovascular diseases.Overall, the TNni2 Rabbit Monoclonal Antibody (CAB4740) is a reliable and versatile reagent for researchers interested in exploring the role of Troponin I in cardiac physiology, pathology, and clinical diagnostics. Its high reactivity and specificity make it a valuable asset in the study of heart disease and muscle disorders.
Product Name:
Troponin I2 (TNNI2) Rabbit Monoclonal Antibody
SKU:
CAB4740
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 83-182 of human Troponin I2 (Troponin I2 (TNNI2)) (P48788).
This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
7136
Clone Number:
ARC1114
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Troponin I2 (Troponin I2 (TNNI2)) Rabbit mAb (CAB4740) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
