TNN Antibody (PACO60444)
- SKU:
- PACO60444
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
TNN Antibody (PACO60444)
The TNN Antibody (PACO60444) is a highly specific and sensitive tool for studying TNN, a key protein involved in cardiovascular function and muscle contraction. This rabbit polyclonal antibody is designed for research purposes and is optimized for use in Western blotting and immunohistochemistry applications. TNN, also known as Troponin C, is a critical component of the troponin complex in muscle cells, where it binds calcium ions and regulates muscle contraction. Abnormalities in TNN expression or function have been linked to various cardiovascular diseases, making it a potential biomarker for heart conditions.
This antibody has been validated for use in human samples, providing researchers with a reliable tool for studying TNN expression and localization in various tissues and cell types. By understanding the role of TNN in muscle function and cardiovascular health, researchers can gain insights into diseases such as cardiomyopathy, heart failure, and skeletal muscle disorders.
| Antibody Name: | TNN Antibody (PACO60444) |
| Antibody SKU: | PACO60444 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Tenascin-N protein (441-556AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO60444 diluted at 1:400 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1 (By similarity). Involved in neurite outgrowth and cell migration in hippocampal explants (By similarity). During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling (By similarity). In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells. Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells. |
| Synonyms: | Tenascin-N (TN-N) (Tenascin-W) (TN-W), TNN, TNW |
| UniProt Protein Function: | TNN: Involved in neurite outgrowth and cell migration in hippocampal explants. Belongs to the tenascin family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; Extracellular matrix Chromosomal Location of Human Ortholog: 1q23-q24 Cellular Component: proteinaceous extracellular matrix; cell surface Molecular Function:integrin binding; identical protein binding Biological Process: cell migration; axonogenesis; cell-matrix adhesion; cell growth |
| UniProt Code: | Q9UQP3 |
| NCBI GenInfo Identifier: | 81175198 |
| NCBI Gene ID: | 63923 |
| NCBI Accession: | Q9UQP3.2 |
| UniProt Secondary Accession: | Q9UQP3,Q5R360, B9EGP3, |
| UniProt Related Accession: | Q9UQP3 |
| Molecular Weight: | 144,034 Da |
| NCBI Full Name: | Tenascin-N |
| NCBI Synonym Full Names: | tenascin N |
| NCBI Official Symbol: | TNNÂ Â |
| NCBI Official Synonym Symbols: | TN-WÂ Â |
| NCBI Protein Information: | tenascin-N; TN-N |
| UniProt Protein Name: | Tenascin-N |
| Protein Family: | Tenascin |
| UniProt Gene Name: | TNNÂ Â |
| UniProt Entry Name: | TENN_HUMAN |
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