The TNKS Polyclonal Antibody (CAB17027) is a key tool for researchers studying the Tankyrase enzyme, an important player in various cellular processes such as telomere maintenance and Wnt signaling. This antibody, produced using rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the TNKS protein, researchers can easily detect and analyze its expression in different cell types, making it an essential tool for studies in molecular biology and cancer research.Tankyrases have been identified as potential therapeutic targets in cancer and other diseases due to their involvement in regulating cell proliferation, DNA repair, and signaling pathways that are often dysregulated in cancer cells.
Understanding the role of TNKS in these processes is crucial for developing targeted therapies that can effectively modulate its activity for therapeutic benefit. The TNKS Polyclonal Antibody provides researchers with a reliable way to investigate the function of Tankyrases and their potential as targets for novel treatments.
Product Name:
TNKS Rabbit Polyclonal Antibody
SKU:
CAB17027
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1050-1150 of human TNKS (NP_003738.2).
Enables histone binding activity; pentosyltransferase activity; and zinc ion binding activity. Involved in several processes, including negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric; protein ADP-ribosylation; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; and protein ADP-ribosylation. Located in several cellular components, including chromosome, telomeric region; mitotic spindle pole; and nucleus.
Purification Method:
Affinity purification
Gene ID:
8658
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TNKS Rabbit pAb (CAB17027) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
