The TNFSF18 Polyclonal Antibody (CAB7028) is a valuable tool for researchers studying TNFSF18, a member of the tumor necrosis factor superfamily known for its role in immune regulation and inflammation. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blot applications. It binds specifically to TNFSF18, allowing for precise detection and analysis in a variety of cell types, making it an excellent choice for studies in immunology and cancer research.
TNFSF18, also known as GITRL, is a key player in regulating immune responses by promoting T cell activation and proliferation. Its involvement in modulating immune function makes it a promising target for research into diseases such as cancer, autoimmune disorders, and inflammatory conditions. Understanding the mechanisms by which TNFSF18 operates is crucial for developing targeted therapies that can manipulate immune responses for therapeutic benefit.
Product Name:
GITR Ligand/TNFSF18 Rabbit Polyclonal Antibody
SKU:
CAB7028
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 52-177 of human GITR Ligand/TNFSF18 (NP_005083.2).
Cell membrane, Single-pass type II membrane protein.
Calculated MW:
20kDa
Observed MW:
44kDa
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells.
Purification Method:
Affinity purification
Gene ID:
8995
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of Rat skeletal muscle, using GITR Ligand/TNFSF18 Rabbit pAb (CAB7028) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
