The TNFSF14 Polyclonal Antibody (CAB2002) is a valuable tool for researchers studying TNFSF14, a member of the tumor necrosis factor superfamily involved in immune regulation. This antibody, generated in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications. It specifically binds to TNFSF14 protein, facilitating its detection and analysis in various cell types, making it ideal for immunology and cancer research studies.TNFSF14, also known as LIGHT (lymphotoxin-like, exhibits inducible expression, and competes with herpes simplex virus glycoprotein D for herpesvirus entry mediator, a receptor expressed by T lymphocytes), plays a crucial role in regulating immune responses and inflammation.
Its involvement in these processes makes it a key target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the function of TNFSF14 is essential for developing therapies that modulate immune responses and inflammation in these pathologies.
Product Name:
TNFSF14/LIGHT Rabbit Polyclonal Antibody
SKU:
CAB2002
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 59-176 of human TNFSF14/LIGHT (NP_003798.2).
Cell membrane, Cytoplasm, Secreted, Single-pass type II membrane protein.
Calculated MW:
26kDa
Observed MW:
28kDa
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported.
Purification Method:
Affinity purification
Gene ID:
8740
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using TNFSF14/LIGHT antibody (CAB2002) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
