TNFSF12 Rabbit Polyclonal Antibody (CAB5659)
- SKU:
- CAB5659
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Description
Product Name: | TNFSF12 Rabbit Polyclonal Antibody |
SKU: | CAB5659 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 42-123 of human TNFSF12 (NP_003800.1). |
Sequence: | VSLG SRAS LSAQ EPAQ EELV AEED QDPS ELNP QTEE SQDP APFL NRLV RPRR SAPK GRKT RARR AIAA HYEV HPRP GQDG AQ |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | APO3L; DR3LG; TWEAK; TNLG4A; TNFSF12 |
Positive Sample: | Mouse lung,Mouse liver,Mouse ovary,Rat lung |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Secreted, Single-pass membrane protein, Single-pass type II membrane protein. |
Calculated MW: | 27kDa |
Observed MW: | 27kDa |
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.
Purification Method: | Affinity purification |
Gene ID: | 8742 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |