The TNFSF12 Polyclonal Antibody (CAB5659) is specifically designed for research involving TNFSF12, a cell surface molecule known for its role in immune regulation and inflammatory responses. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the TNFSF12 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an excellent tool for studies in immunology and cancer research.TNFSF12, also known as TWEAK, is a multifunctional cytokine involved in various cellular processes, such as cell proliferation, differentiation, and apoptosis.
Its role in immune regulation and inflammation suggests its potential as a therapeutic target for diseases like cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the function of TNFSF12 is crucial for developing targeted therapies that modulate immune responses in these disease contexts.Overall, the TNFSF12 Polyclonal Antibody (CAB5659) is a valuable tool for researchers seeking to delve into the complexities of immune regulation and inflammatory pathways, with the ultimate goal of advancing our understanding of disease mechanisms and discovering new therapeutic interventions.
Product Name:
TNFSF12 Rabbit Polyclonal Antibody
SKU:
CAB5659
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 42-123 of human TNFSF12 (NP_003800.1).
Cell membrane, Secreted, Single-pass membrane protein, Single-pass type II membrane protein.
Calculated MW:
27kDa
Observed MW:
27kDa
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.
Purification Method:
Affinity purification
Gene ID:
8742
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using TNFSF12 Rabbit pAb (CAB5659) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
