RANKL Rabbit Polyclonal Antibody (CAB16326)
- SKU:
- CAB16326
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
Product Name: | RANKL Rabbit Polyclonal Antibody |
SKU: | CAB16326 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 78-317 of human RANKL (NP_003692.1). |
Sequence: | RISE DGTH CIYR ILRL HENA DFQD TTLE SQDT KLIP DSCR RIKQ AFQG AVQK ELQH IVGS QHIR AEKA MVDG SWLD LAKR SKLE AQPF AHLT INAT DIPS GSHK VSLS SWYH DRGW AKIS NMTF SNGK LIVN QDGF YYLY ANIC FRHH ETSG DLAT EYLQ LMVY VTKT SIKI PSSH TLMK GGST KYWS GNSE FHFY SINV GGFF KLRS GEEI SIEV SNPS LLDP DQDA TYFG AFKV RDID |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TNLG6B; TRANCE; hRANKL2 |
Positive Sample: | K-562,SW620,A-549 |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm, Secreted, Single-pass type II membrane protein, Single-pass type II membrane protein. |
Calculated MW: | 35kDa |
Observed MW: | 35kDa |
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
Purification Method: | Affinity purification |
Gene ID: | 8600 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |