null

Tnfsf11 Antibody (PACO30706)

SKU:
PACO30706
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS

Tnfsf11 Antibody (PACO30706)

The TNFSF11 Antibody (PACO30706) is a polyclonal antibody developed for research involving TNFSF11, also known as RANKL, a key cytokine involved in bone metabolism and immune system regulation. This antibody, generated in rabbits, has high reactivity with human samples and is validated for use in various applications, including Western blot. By binding to TNFSF11, this antibody allows for the detection and analysis of TNFSF11 protein in different cell types, making it ideal for studies in osteoimmunology and bone biology research.

TNFSF11 is a critical factor in osteoclast differentiation and activation, playing a pivotal role in bone remodeling and resorption. Its ability to regulate bone resorption makes it a potential target for therapeutic intervention in bone-related diseases such as osteoporosis and rheumatoid arthritis. By elucidating the mechanisms by which TNFSF11 operates, researchers can gain insights into new strategies for treating bone disorders and inflammatory conditions that affect bone health.

Antibody Name:Tnfsf11 Antibody (PACO30706)
Antibody SKU:PACO30706
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IF
Recommended Dilutions:ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:Mouse
Immunogen:Recombinant Mouse Tumor necrosis factor ligand superfamily member 11 protein (73-306AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageImmunofluorescent analysis of HepG2 cells using PACO30706 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.
Synonyms:Tumor necrosis factor ligand superfamily member 11 (Osteoclast differentiation factor) (ODF) (Osteoprotegerin ligand) (OPGL) (Receptor activator of nuclear factor kappa-B ligand) (RANKL) (TNF-related activation-induced cytokine) (TRANCE) (CD antigen CD254) [Cleaved into: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form], Tnfsf11, Opgl Rankl Trance
UniProt Protein Function:TNFSF11: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Homotrimer. Up-regulated by T-cell receptor stimulation. Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid. Belongs to the tumor necrosis factor family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral

Cellular Component: extracellular space; membrane; cytoplasm; integral to membrane; plasma membrane; extracellular region; intracellular

Molecular Function:protein binding; cytokine activity; tumor necrosis factor receptor superfamily binding; tumor necrosis factor receptor binding

Biological Process: positive regulation of osteoclast differentiation; multicellular organismal development; positive regulation of JNK cascade; osteoclast differentiation; activation of JNK activity; positive regulation of homotypic cell-cell adhesion; positive regulation of corticotropin-releasing hormone secretion; activation of NF-kappaB transcription factor; calcium ion homeostasis; positive regulation of MAP kinase activity; monocyte chemotaxis; regulation of osteoclast differentiation; tumor necrosis factor-mediated signaling pathway; positive regulation of bone resorption; cell differentiation; protein homooligomerization; bone resorption; ossification; positive regulation of I-kappaB kinase/NF-kappaB cascade; cytokine and chemokine mediated signaling pathway; mammary gland epithelial cell proliferation; lymph node development; positive regulation of protein kinase B signaling cascade; organ morphogenesis; immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; positive regulation of T cell activation; positive regulation of phosphorylation

UniProt Code:O35235
NCBI GenInfo Identifier:342187063
NCBI Gene ID:21943
NCBI Accession:O35235.2
UniProt Secondary Accession:O35235,O35306, Q3TWY5, Q9JJK8, Q9JJK9, Q9R1Y0,
UniProt Related Accession:O35235
Molecular Weight:22,150 Da
NCBI Full Name:Tumor necrosis factor ligand superfamily member 11
NCBI Synonym Full Names:tumor necrosis factor (ligand) superfamily, member 11
NCBI Official Symbol:Tnfsf11  
NCBI Official Synonym Symbols:ODF; OPG; OPGL; RANKL; Ly109l; Trance  
NCBI Protein Information:tumor necrosis factor ligand superfamily member 11; OPG ligand; osteoprotegerin ligand; osteoclast differentiation factor; receptor activator of NF-kappaB ligand; TNF-related activation-induced cytokine; receptor activator of nuclear factor kappa B ligand; receptor activator of nuclear factor kappa-B ligand; tumor necrosis factor-related activation-induced cytokine
UniProt Protein Name:Tumor necrosis factor ligand superfamily member 11
UniProt Synonym Protein Names:Osteoclast differentiation factor; ODF; Osteoprotegerin ligand; OPGL; Receptor activator of nuclear factor kappa-B ligand; RANKL; TNF-related activation-induced cytokine; TRANCE; CD_antigen: CD254Cleaved into the following 2 chains:Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form
UniProt Gene Name:Tnfsf11  
UniProt Entry Name:TNF11_MOUSE
ELISA Kits
Mouse RANkL (Receptor Activator of Nuclear Factor Kappa B Ligand) CLIA Kit (MOES00346)
Mouse RANk (Receptor Activator of Nuclear Factor Kappa B) CLIA Kit (MOES00353)
Mouse Tumor necrosis factor ligand superfamily member 11 (Tnfsf11) ELISA Kit
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
Recommended Products
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011)
Anti-HRP-conjugated Beta Actin Antibody (CABC028)

Related Products