The TNFSF10 Polyclonal Antibody (CAB2138) is a valuable tool for researchers studying TNFSF10, a member of the tumor necrosis factor superfamily known for its role in apoptosis and immune regulation. This antibody is produced in rabbits and is highly specific to human samples, making it ideal for a range of research applications.TNFSF10, also known as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), has been implicated in various cancer types and is being studied for its potential therapeutic applications in cancer treatment.
The TNFSF10 Polyclonal Antibody binds specifically to the TNFSF10 protein, allowing for accurate detection and analysis in a variety of cell types.By using the TNFSF10 Polyclonal Antibody in Western blot applications, researchers can further unravel the mechanisms underlying TNFSF10's role in apoptosis and immune response regulation. This antibody is a valuable tool for enhancing our understanding of TNFSF10's function in cancer and immunology research, paving the way for potential therapeutic advancements in the future.
Product Name:
TNFSF10 Rabbit Polyclonal Antibody
SKU:
CAB2138
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human TNFSF10 (NP_003801.1).
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
8743
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from THP-1 cells, using (CAB2138) at 1:1000 dilution.THP-1 cells were treated by LPS (1 μg/ml) at 37℃ for 8 hours.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
