The TNFRSF8 Polyclonal Antibody (CAB7651) is a valuable tool for researchers studying TNFRSF8, also known as CD30, a cell surface receptor involved in immune response regulation. The antibody is produced in rabbits and is highly specific for human samples, making it ideal for use in Western blot applications. By binding to the TNFRSF8 protein, this antibody allows for precise detection and analysis of TNFRSF8 in various cell types, making it a key asset for studies in immunology and cancer research.TNFRSF8 plays a significant role in immune regulation, particularly in modulating inflammatory responses and regulating immune cell function.
Its involvement in immune homeostasis makes it a potential target for investigating diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the role of TNFRSF8 is essential for the development of therapies that manipulate immune responses in these pathological contexts.Overall, the TNFRSF8 Polyclonal Antibody (CAB7651) provides researchers with a valuable tool for investigating the function and significance of TNFRSF8 in immune regulation and disease pathogenesis.
Product Name:
TNFRSF8 Rabbit Polyclonal Antibody
SKU:
CAB7651
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 500-595 of human CD30 (NP_001234.3).
Cell membrane, Cytoplasm, Single-pass type I membrane protein.
Calculated MW:
64kDa
Observed MW:
128kDa
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Purification Method:
Affinity purification
Gene ID:
943
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CD30 antibody (CAB7651) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
