The TNFRSF4 Polyclonal Antibody (CAB7499) is a powerful tool for researchers studying TNFRSF4, a cell surface receptor involved in regulating immune responses and inflammation. This antibody, generated in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the TNFRSF4 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it suitable for investigations in immunology and oncology research.
TNFRSF4, also known as OX40 or CD134, plays a crucial role in modulating T cell activation and promoting immune responses. Its involvement in regulating immune function makes it a promising target for studying diseases such as cancer, autoimmune disorders, and inflammatory conditions. Understanding the role of TNFRSF4 in immune regulation is essential for developing new therapeutic strategies that manipulate immune responses in these disease settings.
Product Name:
OX40 Rabbit Polyclonal Antibody
SKU:
CAB7499
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 29-214 of human CD134/OX40 (NP_003318.1).
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.
Purification Method:
Affinity purification
Gene ID:
7293
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CD134/OX40 antibody (CAB7499) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 30s.
