The TNFRSF25 Polyclonal Antibody (CAB14261) is a vital tool for researchers studying TNFRSF25, a cell surface receptor essential for regulating immune responses. This antibody, produced in rabbits, has a high degree of specificity for human samples and has been rigorously tested for use in Western blot applications. By binding to the TNFRSF25 protein, this antibody enables precise detection and analysis in a wide range of cell types, making it an invaluable asset for studies in immunology and cancer research.
TNFRSF25, also known as death receptor 3 (DR3), is a key player in immune system function, with important roles in inflammation, autoimmune diseases, and cancer. By understanding the mechanisms by which TNFRSF25 modulates immune responses, researchers can uncover new insights into the development of therapeutic strategies for these conditions. The TNFRSF25 Polyclonal Antibody is a valuable tool for investigating the function and regulation of this crucial receptor in various disease contexts.
Product Name:
TNFRSF25 Rabbit Polyclonal Antibody
SKU:
CAB14261
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 25-190 of human TNFRSF25 (NP_683866.1).
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
45kDa
Observed MW:
60kDa
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.
Purification Method:
Affinity purification
Gene ID:
8718
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TNFRSF25 Rabbit pAb (CAB14261) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
