The TNFRSF1B Polyclonal Antibody (CAB0387) is a valuable tool for researchers studying TNFRSF1B, a member of the tumor necrosis factor receptor superfamily. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By targeting the TNFRSF1B protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an ideal choice for studies in immunology and cancer research.TNFRSF1B, also known as tumor necrosis factor receptor 2, plays a crucial role in regulating inflammatory responses and orchestrating cell death pathways.
Its involvement in immune signaling pathways highlights its importance in various diseases, including cancer, autoimmune disorders, and inflammatory conditions. By investigating the function of TNFRSF1B, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially develop targeted therapies to modulate immune responses effectively.Overall, the TNFRSF1B Polyclonal Antibody (CAB0387) serves as a valuable tool for investigating the role of TNFRSF1B in immune regulation and disease pathogenesis, opening up avenues for innovative research and therapeutic development.
Product Name:
TNFR2/TNFRSF1B Rabbit Polyclonal Antibody
SKU:
CAB0387
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 30-250 of human TNFR2/TNFR2/TNFRSF1B (NP_001057.1).
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
48kDa
Observed MW:
65kDa
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.
Purification Method:
Affinity purification
Gene ID:
7133
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from THP-1 cells, using TNFR2/TNFRSF1B Rabbit pAb (CAB0387) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
