TNFR2/TNFRSF1B Rabbit Polyclonal Antibody (CAB0387)
- SKU:
- CAB0387
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
Product Name: | TNFR2/TNFRSF1B Rabbit Polyclonal Antibody |
SKU: | CAB0387 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-250 of human TNFR2/TNFR2/TNFRSF1B (NP_001057.1). |
Sequence: | TPYA PEPG STCR LREY YDQT AQMC CSKC SPGQ HAKV FCTK TSDT VCDS CEDS TYTQ LWNW VPEC LSCG SRCS SDQV ETQA CTRE QNRI CTCR PGWY CALS KQEG CRLC APLR KCRP GFGV ARPG TETS DVVC KPCA PGTF SNTT SSTD ICRP HQIC NVVA IPGN ASMD AVCT STSP TRSM APGA VHLP QPVS TRSQ HTQP TPEP STAP STSF LLPM GPSP P |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | p75; TBPII; TNFBR; TNFR2; CD120b; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II; TNFR2/TNFRSF1B |
Positive Sample: | THP-1 |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Secreted, Single-pass type I membrane protein. |
Calculated MW: | 48kDa |
Observed MW: | 65kDa |
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.
Purification Method: | Affinity purification |
Gene ID: | 7133 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |