The TNFRSF1A Polyclonal Antibody (CAB1540) is a valuable tool for researchers studying TNFRSF1A, a cell surface receptor involved in inflammation and immune response regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the TNFRSF1A protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal choice for studies in immunology and inflammation-related research.TNFRSF1A, also known as TNF receptor superfamily member 1A, is a key player in the pro-inflammatory signaling pathways, making it a target of interest for research related to inflammatory diseases, autoimmune disorders, and cancer.
Understanding the function and regulation of TNFRSF1A is crucial for developing targeted therapies that modulate the immune response in these contexts.Overall, the TNFRSF1A Polyclonal Antibody (CAB1540) offers researchers a reliable tool to study the role of TNFRSF1A in immune response modulation and inflammation, ultimately contributing to advances in the understanding and treatment of various diseases.
Product Name:
TNFR1/TNFRSF1A Rabbit Polyclonal Antibody
SKU:
CAB1540
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 345-455 of human TNFR1/TNFRSF1A (NP_001056.1).
Cell membrane, Golgi apparatus membrane, Secreted, Secreted, Single-pass type I membrane protein.
Calculated MW:
50kDa
Observed MW:
55kDa
This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients.
Purification Method:
Affinity purification
Gene ID:
7132
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TNFR1/TNFRSF1A Rabbit pAb (CAB1540) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
