The TNFRSF18 Polyclonal Antibody (CAB15625) is a vital tool for researchers studying TNFRSF18, a cell surface receptor involved in immune regulation and immune tolerance. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been rigorously validated for Western blot applications. By specifically targeting the TNFRSF18 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential tool for investigations in immunology and cancer research.TNFRSF18, also known as glucocorticoid-induced TNFR-related protein (GITR), plays a crucial role in balancing immune responses by promoting effector T cell function and inhibiting regulatory T cell activity.
The importance of TNFRSF18 in immune regulation makes it a promising target for research exploring cancer immunotherapy, autoimmune diseases, and inflammatory conditions. Unraveling the mechanisms underlying TNFRSF18 activity is essential for developing new therapeutic strategies that modulate immune responses in these disease contexts.
Product Name:
GITR/TNFRSF18 Rabbit Polyclonal Antibody
SKU:
CAB15625
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 26-255 of human GITR/TNFRSF18 (NP_683699.1).
external side of plasma membrane, extracellular region, plasma membrane
Calculated MW:
26kDa
Observed MW:
30kDa
This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Purification Method:
Affinity purification
Gene ID:
8784
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using GITR/TNFRSF18 Rabbit pAb (CAB15625) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
