The TNFRSF11B Polyclonal Antibody (CAB13250) is a valuable tool for researchers studying TNFRSF11B, a member of the TNF receptor superfamily which is involved in osteoclast differentiation and activation. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in various applications such as Western blot and immunohistochemistry.TNFRSF11B, also known as Osteoprotegerin (OPG), acts as a decoy receptor for RANKL (Receptor Activator of Nuclear Factor Kappa-B Ligand), thereby regulating bone remodeling and osteoclastogenesis. Dysregulation of the RANKL/OPG pathway has been implicated in diseases such as osteoporosis, rheumatoid arthritis, and cancer bone metastasis.
By targeting TNFRSF11B, researchers can gain insights into the mechanisms underlying these conditions and potentially develop new therapeutic strategies.With its high specificity and reliability, the TNFRSF11B Polyclonal Antibody (CAB13250) is a valuable tool for scientists studying the role of TNFRSF11B in bone biology, cancer, and other diseases characterized by aberrant osteoclast activity. Its use in various research applications makes it an essential component of any immunology or bone research laboratory.
Product Name:
TNFRSF11B Rabbit Polyclonal Antibody
SKU:
CAB13250
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-280 of human TNFRSF11B (NP_002537.3).
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
Purification Method:
Affinity purification
Gene ID:
4982
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TNFRSF11B antibody (CAB13250) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
