The TNFRSF11A Polyclonal Antibody (CAB12997) is a valuable tool for researchers studying TNFRSF11A, a cell surface receptor involved in bone metabolism and immune regulation. This antibody, produced in rabbits, shows high specificity and reactivity with human samples, making it ideal for use in Western blot applications. By binding to the TNFRSF11A protein, this antibody enables accurate detection and analysis in various cell types, supporting research in areas such as immunology and bone biology.TNFRSF11A, also known as RANK, plays a crucial role in osteoclast differentiation and activation, making it a key target in studies related to bone health and diseases such as osteoporosis and bone cancer.
Additionally, TNFRSF11A is involved in immune regulation and has been implicated in conditions such as rheumatoid arthritis and inflammatory bone diseases. Understanding the function and regulation of TNFRSF11A is essential for developing novel therapies aimed at targeting bone-related disorders and immune-mediated conditions.
Product Name:
TNFRSF11A Rabbit Polyclonal Antibody
SKU:
CAB12997
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 466-616 of human TNFRSF11A (NP_003830.1).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
66kDa
Observed MW:
80kDa
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus.
Purification Method:
Affinity purification
Gene ID:
8792
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TNFRSF11A Rabbit pAb (CAB12997) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
